At the heart of the book are a series of five projects, which take the reader from the fundamentals of logic and pulse circuits to more advanced design aspects and analysis of digital circuits. The projects are constructed in a way that gives the reader insight into and an understanding of how things actually work. The projects are divided into two sets of three projects. The first set covers the more elementary topics. The projects in this set include: * Pulse signalling - Use pulse counting to get pulses. This project is based around a simple pulse counter. * Pulse frequency - This project explores the effects of pulse generation frequency on the output voltage. * Pulse generation - This project explores the effects of pulse width and pulse repetition rate. * Pulse rate - This project explores the effects of pulse width and pulse repetition rate. The second set of three projects cover the more advanced topics. They are: * Pulse propagation - This project explores how a pulse from an input can be controlled or blocked by a circuit, and how signals can be made to travel through a pulse. * Pulse filter - This project looks at pulse filters and how they can be used to reject noise. * Pulse and digital circuit analysis - This project looks at how digital circuits can be analysed and simulated using PSpice. * A full index is included, which lists all of the projects, as well as glossaries, references and a bibliography. Keywords: * circuit analysis; digital circuits; computer aided design; digital design and simulation; logic circuits; pulse logic circuits; PSpice; pulse electronicsVery little is known about the functions and regulation of the cyclin C gene, although previous studies of Ccnc, the mouse ortholog, have demonstrated that it is necessary for entry into the cell cycle. Mice heterozygous for Ccnc have a marked reduction in body weight, and a postmitotic neuronal culture system in which Ccnc is expressed is impaired for the morphological differentiation of neurons. Moreover, differentiated neuroblastoma cells (N-2a) ectopically expressing Ccnc become more resistant to the cytotoxic effects of growth inhibitory drugs. These results suggest a critical role for cyclin C in neuronal survival. We propose to test this hypothesis with specific aims: 1) to study the relationship between Ccnc and the G2M transition, 2) to characterize Ccnc-mediated changes in neuronal survival and cell cycle, and 3) to identify and clone upstream regulatory sequences for Ccnc in mammalian cells. To achieve the specific aims, we
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